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Our exogenous histamine intake relies on something called DAO to metabolize it. DAO, or diamine oxidase,is the primary barrier for intestinal histamine absorption. Some of people are born with a deficiency in the production of DAO, which
causes us to not be able to breakdown histamine properly. This results in excess histamine in the body, which can wreak havoc and cause symptoms such as bloat, feeling excessively full after eating or drinking, diarrhea, abdominal pain, itchiness, hives, flushing, congestion, headache, dizziness, fast
heart rate, and anxiety. Additionally, deficiencies of copper, vitamin C, and pyridoxine can also result in reduced activity of DAO. And, fascinatingly enough, the phase of the menstrual cycle can also affect how effective DAO is at breaking down histamine in our gut.